中國藥理學(xué)與毒理學(xué)雜志(2016年10期)
Chinese Journal of Pharmacology and Toxicology

目 錄

• 國際合作助推青年人才成長——“中國藥理學(xué)會-施維雅青年藥理學(xué)工作者獎”設(shè)立20周年
• 先導(dǎo)物發(fā)現(xiàn)的新方法（英文）
• 健康與疾病狀態(tài)下腦部鈣信號傳導(dǎo)（英文）
• 一氧化氮研究三十年:自優(yōu)而劣（英文）
• 二甲雙胍藥代動力學(xué)與藥效學(xué)的個體差異（英文）
• 阿拉斯加原住民藥物基因組學(xué)發(fā)現(xiàn)與臨床相關(guān)性（英文）
• 從神經(jīng)元的分子調(diào)控到認知與記憶（英文）
• 運動皮質(zhì)的塑性:多巴胺的神經(jīng)分布（英文）
• AngⅡ誘導(dǎo)兔動脈粥樣硬化下肢再狹窄磷酸化JAK/STAT信號傳導(dǎo)調(diào)控機制的實驗研究
• 阿司匹林和氯吡格雷聯(lián)合應(yīng)用致急性心肌梗死后大鼠胃黏膜損傷和微血管變化的藥理機制初探
• 心肌損傷修復(fù)過程中的細胞交互作用機制研究
• DRAM1通過改善自噬流抗心肌缺血損傷
• 川穹嗪對腎性高血壓大鼠心肌重構(gòu)及P38MAPK/AP-1信號通路的影響
• 硫化煙酸對血管內(nèi)皮細胞損傷模型的保護作用
• 白藜蘆醇通過調(diào)節(jié)PGC-1α活性與線粒體功能抑制多柔比星心肌細胞損傷
• 轉(zhuǎn)化生長因子β_1/Smad信號通路在肺動脈高壓中的作用
• 甜菜堿對大鼠心肌肥厚的保護作用及機制
• 內(nèi)皮祖細胞對實驗兔動脈粥樣硬化再狹窄模型調(diào)控功能的研究
• Salvianolic acid A attenuates isoproterenol-induced myocardial infarction in mice through PI3K/Akt signal pathway
• Caffeoylquinic acid derivatives extract of Erigeron multiradiatus alleviated acute myocardial ischemia reperfusion injury in rats through inhibiting NF-kappaB and JNK activations
• The role of HSPB1 and ectopic F1Fo-ATPase interaction in hypoxia pulmonary hypertension vascular adventitial vasa vasorum remodeling
• Effects of hydrogen-rich saline on platelet activation in hypertensive rats
• DDAH1-V3 transcript might act as miR-21 sponge to maintain balance of DDAH1-V1 in cultured HUVECs
• J24924 possesses cardiovascular and renal protective effects on pristane-induced lupus through inhibition of RhoA/Rho kinase pathway in mice
• UCN enhances TGF-β-mediated mitoinhibition of VSMCs via counteracting TGF-β-induced cPLA2 expression and activation
• Calpain mediated pulmonary vascular remodeling in hypoxia induced pulmonary hypertension
• Ginkgolide K protects the heart against ER stress injury by activating the IRE1α/XBP1 pathway
• Cerebral vasorelaxant material basis of Xiaoxuming decoction study with rat basilar artery
• Regulation of microRNAs in cell signaling pathways-mediated vascular remodeling
• DL0805 derivatives protect the pulmonary arterial cells via the RhoA/ROCK pathway
• Salvianolic acid A attenuates vascular remodeling in a pulmonary arterial hypertension rat model
• 毒品的神經(jīng)免疫藥理學(xué)及創(chuàng)新藥物發(fā)現(xiàn)
• 質(zhì)量標(biāo)準(zhǔn)化的紅花黃酮類提取物抗帕金森病的藥效學(xué)評價
• 間苯三酚類衍生物WYD1-8抑制神經(jīng)炎癥作用機制的研究
• 百可利對魚藤酮致帕金森病模型的神經(jīng)保護作用
• 百可利對魚藤酮誘導(dǎo)的帕金森病模型大鼠腦組織抗氧化能力的影響
• MPTP致慢性帕金森病小鼠模型的潛在生物標(biāo)記物及藥物靶點的研究
• 蒙藥嘎日迪-13對腦缺血損傷大鼠MPO表達的影響
• 丁苯酞的抗焦慮作用及機制研究
• 癲癇發(fā)作和抗癲癇藥物誘導(dǎo)共同導(dǎo)致耐藥性癲癇腦中P-糖蛋白過表達
• 以Nampt/SIRT1為靶點探索通絡(luò)醒腦泡騰片抗氧化應(yīng)激作用
• 桃紅四物湯對魚藤酮誘導(dǎo)帕金森細胞模型保護作用
• 紅景天苷促大鼠腦缺血再灌注腦組織的神經(jīng)再生作用
• 丹酚酸A對大鼠腦缺血再灌注損傷的保護機制
• DL0410改善APP/PS1轉(zhuǎn)基因小鼠學(xué)習(xí)記憶的作用機制
• 銀杏二萜內(nèi)酯對缺血再灌注大鼠腦組織中神經(jīng)遞質(zhì)的影響
• DL0410對APP/PS1轉(zhuǎn)基因小鼠的神經(jīng)保護作用
• 兩種線粒體復(fù)合體抑制劑擬PD動物模型的建立及行為學(xué)檢測
• 匹諾塞林對大鼠腦梗死后rtPA誘導(dǎo)的出血性轉(zhuǎn)化的預(yù)防作用及機制
• 復(fù)方柴歸方抗抑郁藥效學(xué)特點
• 培元解郁方對急慢性應(yīng)激BALb/c小鼠的抗抑郁作用及TRY-KYN代謝途徑的調(diào)節(jié)
• 斯皮諾素誘導(dǎo)小鼠非快動眼睡眠
• 白藜蘆醇抑制星形膠質(zhì)細胞氧化應(yīng)激的細胞內(nèi)作用機制
• BKCa通道在適度酒精預(yù)適應(yīng)保護腦缺血再灌注損傷中的作用及ROS的調(diào)控機制
• 以炎癥為靶點治療慢性缺血后的腦白質(zhì)損傷
• Neuroprotective effect of Angiopep-2 peptide modified scutellarin-loaded PEGylated PAMAM dendrimer nanoparticles on ischemic stroke by modulating the Toll-like receptors-dependent MyD88/IKK/NF-κB signaling pathway
• The neuroprotective effect of Rhodiolae on dementia rat induced by ibotenic acid
• Lentivirus-mediated knockdown of phosphodiesterase 4D improved depression-like behaviors in mice
• Melatonin alleviates lipopolysaccharide-compromised integrity of blood brain barrier by activation of AMP-activated protein kinase in old mice
• Propane-2-sulfonic acid octadec-9-enyl-amide,a novel PPARα/γ dual agonist,protects against ischaemiainduced brain damage in mice by inhibiting inflammatory responses
• The effects of 5-lipoxygenase inhibitor and cysteinyl leukotriene receptor 1 antagonist on 1-methyl-4-phenylpyridine-induced neurotoxicity
• Attenuation of Scutellaria barbata flavonoids on cortical cytoplasm apoptotic factors disorders induced by complex Aβ_(25-35) in rats
• Moderate alcohol preconditioning activates BKCa channels to protect brain damage-induced by cerebral ischemia and reperfusion
• Isoliquiritigenin suppresses microglial activation and neuroinflammation in primary microglia
• Inhibition of chemokine-like factor 1 improves bloodbrain barrier dysfunction in rats following focal cerebral ischemia
• Hippocampal PPARδ downregulation contri butes to depressive phenotype with decreased neurogenesis
• Adenosine A2A receptor-expressing neurons in the striatum regulate sleep behaviors
• Natural product compound 3c ameliorates brain inflammation and brain ischemic stroke via AMPK-mediated microglia polarization
• Modulation of abnormal neuronal circuit in temporal lobe epilepsy
• The basic helix-loop-helix(bHLH)transcription factor,DEC1,provides neuroprotection from apoptosis induced by MPP~+ through PI3K/Akt pathway in SHSY5Y cells
• Mechanical allodynia and affective behavior are improved by INI-0602,a gap junction hemichannel inhibitor,in a rat model of neuropathic pain induced by sciatic nerve injury
• Synergistic use of geniposide and baicalin on BV2 cell activation damage caused by LPS
• Neuroprotective effects of kaempferol against 2VO-induced chronic cerebral ischemia in rats
• Xiao-xu-ming decoction inhibits lipopolysaccharide induced neuroinflammation in mice
• The extract of Ramulus Cinnamom attenuates inflammatory injury induced by LPS via regulation of TLR4/MyD88 signaling pathway in BV2 cells
• Ginkgo biloba extract-761 improves the motor functions in permanent middle cerebral artery occlusion rats
• Chemogenetic activation of sublaterodorsal tegmental glutamatergic neurons alleviates rapid eye movement sleep behavior disorder symptoms in a chronic rat model of Parkinson disease
• 人參地黃桑葚片對小鼠免疫功能的影響
• 利用斑馬魚模型研究姜黃素抗炎的分子機制
• 雙環(huán)醇抗炎作用機制研究
• 蝦青素對博來霉素致大鼠肺纖維化的干預(yù)作用及機制
• 炎癥免疫反應(yīng)軟調(diào)節(jié)—藥物研究新方向
• 二仙膏對化療后白細胞減少癥的藥效作用
• 不同提取方法及給藥途徑的腸腑康膠囊對大鼠脾虛型潰瘍性結(jié)腸炎的影響
• 白虎加桂枝湯對熱痹模型大鼠特征性甲基化基因表達的影響
• 雷公藤內(nèi)酯醇LLDT-8在抗GBM抗體誘導(dǎo)小鼠腎炎中的療效作用及對Fc受體介導(dǎo)淋巴細胞活化的調(diào)控機制
• DL1502新晶型對骨關(guān)節(jié)炎模型的治療作用
• 神經(jīng)酰胺類鞘脂及其代謝通路參與免疫性肝纖維化發(fā)生發(fā)展的作用研究
• 構(gòu)樹果汁體外抗氧化及對小鼠免疫調(diào)節(jié)作用
• 清除衰老細胞治療小鼠放射性肺纖維化機制
• 異甘草酸鎂對小鼠放射性肺纖維化的改善作用及其機制的初步探討
• Interaction of Wnt/β-catenin and Nrf2 pathways in cigarette smoke-induced inflammation and emphysema
• Nrf2 inhibits epithelial-mesenchymal transition by suppressing snail expression during pulmonary fibrosis
• Anti-inflammatory effect of extracts of Dendropanax dentige and Lycopodiastrum casuarinoides on rheumatoid arthritis and their underlying mechanism in rats
• Increased BAFF in serum is a novel biomarker related to disease activity in rheumatoid arthritis
• Matrine ameliorates experimental autoimmune encephalomyelitis by regulating the differentiation of encephalitogenic Th1/Th17 and Th2/regulatory T cells
• Mechanism of TSCS promote anti-Fas antibody-induced FLS apoptosis via blocking MC-tryptase-PAR-2-Rho-FLS signaling pathway
• The GSK3b sensing metabolism controls NLRP3 inflammasome activation
• Curcuma′s extraction attenuates propranolol-induced psoriasis like in mice by inhibition of keratin,proliferating cell nuclear antigen and Toll-like receptor expression
• Salvianolic acid A alleviates renal injury in systemic lupus erythematosus induced by pristane in BALB/c mice
• 臨床常用普伐他汀鈉片大鼠體內(nèi)藥代動力學(xué)比較研究
• 孕三烯酮膠囊多次給藥在巴馬小型豬體內(nèi)的藥代動力學(xué)研究
• KCNQ鉀通道在糖尿病神經(jīng)病理性疼痛中的作用及機制研究
• 采用雙向驗證法和斑馬魚模型探索血管生成相關(guān)的內(nèi)源性代謝物及代謝網(wǎng)絡(luò)的變化
• 液質(zhì)聯(lián)用法同時測定新西蘭兔血漿中左炔諾孕酮和炔雌醇及其藥動學(xué)
• 基于~1H-NMR代謝組學(xué)技術(shù)研究D-半乳糖致衰老大鼠尿液的動態(tài)變化
• 抗癲癇新藥氯桂丁胺與藥物代謝酶CYP450的相互作用
• 性激素對二乙基亞硝胺(DEN)所致肝癌組織中CYP450酶表達的影響
• 新型利尿藥PU-48在生物樣本中LC-MS/MS檢測方法的建立與確證
• 基于~1H-NMR代謝組學(xué)的黃芩素干預(yù)D-半乳糖致衰老大鼠作用研究
• 杜仲降血壓活性成分在正常大鼠和自發(fā)性高血壓大鼠體內(nèi)的藥代動力學(xué)差異研究
• 伏立康唑血藥濃度監(jiān)測結(jié)果評析
• 細胞外Ba~(2+)對記錄大鼠心肌細胞L型鈣通道的影響
• Inhibitory effect of plumbagin,a potential anticancer natural compound,on cytochrome P450 2J2 in humans
• Review on the effects of the traditional Chinese medicine on cytochrome P450
• Pharmacokinetic parameters investigation on interaction between Danshen injection and Honghua injection
• Microdosing cocktail study on the determination and pharmacokinetics of six hepatic cytochrome probes and their metabolites in rat
• Translational regulation of RPA2 via IRES by UNR and e IF3a
• The anti-nociceptive effect of bufalin,an active ingredient from toad venom via modulating voltage-gated sodium channels
• MLKL forms cation channels
• Characteristics and pharmacokinetics of tripterygium glycosides nano-carries transdermal delivery systems:skin-blood synchronous microdialysis and numerical simulation
• A genome-wide association study identifies novel genetic loci that modify pharmacokinetic-pharmacodynamic responses to clopidogrel
• Generation and characterization of a novel CYP3A1/2 double knockout rat model using CRISPR-Cas9 system
• Histone methylation and acethylation contribute to rifampin-mediated induction of CYP3A4 through the interactions between PXR and NCOA6/p300
• TMEM16A contributes to endothelial dysfunction through accelerating Nox2 NADPH oxidase-derived ROS generation in hypertension
• Effects of FOXO1 mediated regulation of mitochondrial function in diabetic wound healing
• Translational regulation of DNA repair systems by eIF3a in cancer chemotherapeutic response
• 長效GLP-1類似物HYHN抗糖尿病藥理作用評價
• 高表達Sptlc2基因促油酸誘導(dǎo)的HSC-T6細胞凋亡及自噬
• Sirt1在高糖刺激腎小球微血管內(nèi)皮細胞損傷中的作用
• 依帕司他對2型糖尿病大鼠肝纖維化的影響
• 利拉魯肽對糖尿病大鼠腎損傷過程中MyD88蛋白表達及炎癥因子的影響
• 孕期炎癥刺激致子代大鼠血脂異常的機制初探
• 大黃酸在中毒性腎功能損傷中的保護作用
• 粗壯女貞總苷降血脂作用及其基于AMPK通路的降脂作用機制
• 茶黃素降低黃嘌呤聯(lián)合氧嗪酸鉀誘導(dǎo)高尿酸血癥小鼠的血漿尿酸作用及機制探究
• 七斛血糖制劑對KK-A~y小鼠降糖作用
• 基于藥理學(xué)和代謝組學(xué)技術(shù)闡明慢性腎衰竭的作用機制及麥角甾酮抗腎纖維化
• 黃芪甲苷對鏈脲佐菌素誘導(dǎo)糖尿病大鼠腎保護機制探討
• 低分子量褐藻多糖硫酸酯改善白蛋白超載引起的腎小管細胞損傷
• 果糖1,6二磷酸酶抑制劑cpd-36在四氧嘧啶小鼠中的降糖作用研究及機制初探
• Hepatic NAD~+ deficiency as a therapeutic target for NAFLD in aging
• Apelin/APJ system and kidney disease
• Ameliorative effect of berberine on high-fat diet/streptozotocin-induced early diabetic nephropathy in rats
• Activation of peripheral KCNQ channels relieves gout pain
• Protective effects of total triterpenoids extracts from Cyclocarya paliurus(Batal.)Iljinskaja on STZ-stimulated INS-1 cells through regulating of autophagy and apoptosis
• Berberine enhanced antidiabetic effects and attenuated untoward effects of canagliflozin in streptozotocininduced diabetic mice
• Disruption of hepatic lipid homeostasis is involved in valproate-induced hepatotoxicity
• 雷公藤紅素在乳腺癌中破壞mTOR蛋白穩(wěn)定性的研究
• NO供體藥JS-K對HepG2.2.15細胞的增殖抑制研究
• NO供體JS-K誘導(dǎo)人肝癌細胞凋亡及其機制的研究
• 黃酮類化合物的抗腫瘤作用
• 星形膠質(zhì)細胞瘤甲基化和非編碼RNA表觀基因組學(xué)研究
• 循環(huán)腫瘤細胞檢測與腫瘤療效關(guān)系的研究
• 增強型ARMS PCR檢測腦膠質(zhì)瘤中IDH1基因突變方法的建立
• MAL基因的表觀遺傳學(xué)調(diào)控對NSCLC吉非替尼敏感性的影響
• 子宮內(nèi)膜癌藥物治療研究進展
• DL1106與doxorubicin和paclitaxel協(xié)同作用及其機制研究
• 抑制細胞自噬的三陰性乳腺癌防治新策略
• 2-苯基-3,4-噻二唑[3,2-α]并嘧啶-7-酮(TPh)對人肝癌細胞HepG2細胞周期、凋亡及相關(guān)因子表達的影響
• 基于共晶體結(jié)構(gòu)設(shè)計全新PARP1抑制劑的合成及在三陰性乳腺癌中誘導(dǎo)凋亡機制的研究
• 新型的eEF2K抑制劑BL-EKI03在乳腺癌中誘導(dǎo)自噬和凋亡作用機制研究
• 天然多酚化合物對PC9/G細胞Gef敏感性和MAL基因表達的影響
• IDH突變通過影響GNG基因表達而影響低級別腦膠質(zhì)瘤患者預(yù)后
• 腫瘤抑素改造T-7R肽體外抗腫瘤活性研究
• 化瘀丸通過血小板介導(dǎo)的肝素酶途徑對4T1乳腺癌的抑制作用
• 菊苣酸對HL-60誘導(dǎo)的白血病小鼠的治療作用及機制研究
• 人U87-MG腦膠質(zhì)瘤細胞裸鼠原位移植模型的建立
• 巨噬細胞的免疫重塑:防治腫瘤轉(zhuǎn)移的新靶點
• Porous Pt nanoparticles for cancer photothermal therapy
• Dysregulation of metallothionein and circadian genes in human hepatocellular carcinoma
• DNMT3A genetic polymorphisms predict disease prognosis in R882 mutation negative AML patients
• MiR-194 functions as a tumor suppressor in laryngeal squamous cell carcinoma by targeting Wee1
• Baicalin inhibits cell growth and induces autophagy via AMPK/ULK1 activation in MDA-MB-231 cells
• Carnitine palmitoyl transferase 1C regulates tumor cell senescence
• Gold nanorods for gambogicacid intracellular delivery
• Inhibitory effects of lapachol on rat C6 glioma in vitro and in vivo by targeting DNA topoisomerase Ⅰ and topoisomerase Ⅱ
• Zeylenone promotes apoptosis of chronic myelogenous leukemia-derived K562 cells by a mechanism involving Jak2 and src kinase
• Spatholobus suberectus column extract inhibit estrogen receptor positive breast cancer
• Gap junctions enhance the antiproliferative effect of microrna-124-3p in glioblastoma cells
• PTEN bridges protective autophagy and apoptosis induced by DNA damage mediated by reactive oxygen species(ROS)in response to cucurbitacin B in hepatocellular carcinoma cells
• Actinomycin D synergistically enhances the efficacy of CDDP by activating P53-PUMA pathway via downregulating P53-MDM2 complex on KB cells
• Resistin contributes to lung adenocarcinoma progression by TLR4/EGFR/PI3K/NF-KB pathway
• In vitro and in vivo evaluation of fisetin as an anticancer agent for breast cancer
• GRK2 overexpression inhibits IGF1-induced proliferation and migration of human hepatocellular carcinoma cells by down-regulating EGR1
• Combination of metformin and curcumin exhibits synergistic inhibitory effects on tumor growth and metastasis in HepG2 cells
• Depletion of PINK1 sensitizes breast cancer cells to polyphyllin Ⅰ via mitophagy suppression and DRP1-mediated mitochondrial fission
• Perspectives on bone-targeted nano-drug carriers for bone tumor treatment
• Enoxaparin sensitizes human non-small-cell lung carcinomasto gefitinib by inhibiting DOCK1 expression,vimentin phosphorylation,and Akt activation
• Effects of garcinone E on ovarian cancer cells:endoplasmic reticulum stress,apoptosis,migration and invasion inhibition
• GubenyiliuⅡ inhibits breast tumor growth and metastasis associated with decreased heparanase expression and Akt phosphorylation
• Different gap junction-propagated effects on cisplatin transfer result in opposite responses to cisplatinin normal cells versus tumor cells
• Gap junctions enhance the antiproliferative effect of microrna-34a in glioma cells
• A polymorphism in GAS5 promoter impacts efficacy of cytarabine-based chemotherapy in Chinese AML patients
• 3-O-(Z)-coumaroyloleanolic acid overcomes Cks1b-induced chemoresistance in lung cancer by inhibiting Hsp90 and MEK pathways
• 山沉香超微粉、原粉與沉香超微粉、原粉藥理學(xué)作用對比研究
• 藏藥保肝作用及機制研究進展
• 十全大補丸對麻醉大鼠血壓的影響
• 理氣活血中藥組分對球囊損傷合并糖尿病高脂飲食大鼠下肢缺血模型的影響
• 斑馬魚模型體內(nèi)評價野生冬蟲夏草的功效
• 晚期糖基化終產(chǎn)物裂解劑秦皮甲素的安全藥理學(xué)研究
• 中藥提取物治療男性不育研究進展
• 針對不同靶點藥物合用藥效相加的規(guī)律和精確計算協(xié)同/相加/拮抗效應(yīng)通用方法的建立
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