中國藥理學與毒理學雜志(2017年10期)
Chinese Journal of Pharmacology and Toxicology

目 錄

• Estrogen weakens muscle endurance via estrogen receptor-MAPK mediated orosomucoid suppression
• Bile salt derivatives with novel skeleton from sea lamprey function as putative pheromone
• MLKL forms cation channels
• 絡(luò)病研究與轉(zhuǎn)化醫(yī)學（英文）
• 中國中藥和天然產(chǎn)物的藥理學研究（英文）
• 小檗堿——抗能量代謝紊亂的新機制藥物（英文）
• 系統(tǒng)篩選與評價作為天然產(chǎn)物-藥物相互作用藥代動力學沉淀劑的天然產(chǎn)物的方法（英文）
• 鑒定植物天然產(chǎn)物生物活性組分的新方法（英文）
• 反向藥物動力學導向的中藥藥物靶標發(fā)現(xiàn)及機制研究（英文）
• Saikosaponins-b suppresses tumor growth and angiogenesis of hepatocellular carcinoma by regulating VEGF/ERK/HIF-1α signal pathway
• Saikosaponin-b regulates the proliferation and apoptosis of HepG2 cells by targeting the MACC1/c-Met/Akt signaling pathway
• A novel anti-inflammatory and immunomodulatory drug CP-25 alleviated collagen induced arthritis by down-regulating BAFF-NF-κκB signaling pathway
• Improved anti-tumor efficacy and pharmacokinetics of bufalin via PEGylated liposomes
• Progress in preventive effects of cordyceps sinensis on ischemic brain
• Ginsenoside metabolite compound K alleviate collegen-induced arthritis through impairing dendritic cells function
• Effects of LW-AFC,a new formula derived from Liuwei Dihuang decoction,on intestinal microbiome in senescence-accelerated mouse prone 8 strain,a mouse model of Alzheimer disease
• Protective effects of imperatorin against cerebral ischemia/reperfusion-induced oxidative stress through Nrf2 signaling pathway in rats
• Xiaochaihutang attenuates liver fibrosis in rats through activation of Nrf2 pathway
• LW-AFC and its active components ameliorate corticosterone-induced long-term potentiation impairment in mice
• Effect of Shenfu injection on microcirculation effect index in early-and middle-stage of cardiogenic shock rats
• Wudang cherry ameliorates urate underexcretion and renal dysfunction in hyperuricemic mice
• Research progress of tonic Chinese medicine on the immune system
• Protective effect and its mechanism of codonopsis pilosula polysaccharide on memory consolidation disorder induced by cycloheximide in mice
• Lychee seed saponins improve cognitive function and ameliorate hippocampal neuronal injury in Alzheimer disease rat model induced by Aβ_(25-35) through AKT/GSK3β pathway
• Beneficial effect of berberine on atherosclerosis based on attenuating vascular inflammation and calcification
• Protective estrogen-like properties and mechanism of quercetin in rat cerebral cortex neurons
• Neuroprotection of quercetin on central neurons against chronic high glucose through enhancement of Nrf2/Glo-1 mediated by phosphorylation regulation
• Herb-herb interaction in traditional Chinese medicine:a review of pharmacokinetics-based interaction in Herb-Pairs
• Mechanistic study on the pharmacokinetic process of salidroside in hypoxic rats
• Ginsenoside Rg1 attenuates motor impairment and neuroinflammation in the MPTP-probenecid-induced parkinsonism mouse model
• Neuroprotective effect of quercetin on beta-amyloid-induced PC12 cells injury and potential related mechanism
• LW-AFC,a new formula derived from Liuwei Dihuang decoction,ameliorates behavioral and pathological deterioration via modulating the neuroendocrine-immune abnormalities in PrP-hAβPPswe/PS1~(ΔE9) transgenic mice
• Comprehensive regulation of traditional Chinese medicine on proliferation and differentiation of neural stem cells
• Onjisaponin B derived from Radix Polygalae enhances autophagy and accelerates the degradation of mutant α-Synuclein and Huntingtin in PC-12 cells
• Dimethyl sulfide,a metabolite of the marine microorganism,protects SH-SY5Y cells against 6-hydroxydopamine and MPP~+-induced apoptosis
• Review for treatment and signaling pathway regulation of kidney-tonifying traditional Chinese medicine on osteoporosis
• Inhibitory effects of lapachol on rat C6 glioma in vitro and in vivo by targeting DNA topoisomeraseⅠ and topoisomeraseⅡ
• Ganoderma triterpenes slow cyst growth in polycystic kidney disease
• Inhibitory effect of baicalein on mice tremor induced by oxotremorine and mechanisms
• 20C,a new bibenzyl compound,plays a significant role in rotenone-induced oxidative insult
• Application of an ultra performance liquid chromatography-tandem mass spectrometry method to the pharmacokinetics study of paeoniflorin-6‘-O-benzene sulfonate and its active paeoniflorin metabolite in rat plasma
• Enhanced anti-cancer effect of gambogic acid by gold nanorod-based delivery
• Salvianolic acid A ameliorates AGEs-induced glomerular endothelial dysfunction and protects against diabetic nephropathy
• Advances in research on chemical constituents,pharmacological actions and processing of atractylodes macrocephala
• Neuroprotective effect of LSS on Aβ_(1-42)-induced BV-2 microglial cells through the inhibition of neuroinflammation
• Effect of Guizhi Fuling capsule and its extracts on human breast cancer cells proliferation
• Inhibition of miR-873 provides therapeutic benefit in lipopolysaccharide-induced Parkinson disease animal model
• Protective role of brain CYP2J in diverse Parkinson disease animal models
• Effects of immunoglobulin D on expression of IgD receptor and protein tyrosine kinase signaling in human CD4~+ T cells
• miRNA-124 in immune system and immune disorders
• Function of IgD on lymphocyte activation and effect of hIgD-Fc-Ig fusion protein on human PBMC proliferation
• Analysis of the key networks,metabolic pathways,and regulation substances of hypoxia based on the omics and zebrafish model
• Amelioration of mitochondrial dysfunction in heart failure through S-sulfhydration of Ca~(2+)/calmodulin-dependent protein kinase Ⅱ
• Meta-analysis of serum copper and heart failure
• Studies on the mechanism of SIRT1/AMPK signaling pathway between hepatocytes and hepatic stellate cells
• Nicotine protects against ulcerative colitis through regulating microRNA-124 and STAT3
• 以G蛋白偶聯(lián)受體為靶標的自身免疫性疾病的治療（英文）
• G protein coupled receptors signaling pathways implicate in inflammatory and immune response of rheumatoid arthritis
• Cellular and molecular perspectives of macrophage in rheumatoid arthritis
• Specific role of synovial macrophages in rheumatoid arthritis
• Protective role of FoxO transcription factors against oxidative stress-induced chondrocyte dysfunction:a new therapeutic target for osteoarthritis
• Cell-based therapy for management of osteoarthritis
• Restoration of E-cadherin by compound 8J protects against cisplatin-induced acute kidney injury by attenuating inflammation and programmed cell death
• Inhibition of cervical cancer cell proliferation and cervical tumorigenicity caused by farnesoid X receptor activation or over-expression is related to CDKN2A-p14~(ARF)-MDM2-p53 pathway
• Non-junctional Cx32 mediates anti-apoptotic and pro-tumor effects via epidermal growth factor receptor in human cervical cancer cells
• TRPA1 channel mediates organophosphate-induced delayed neuropathy
• Gap junctions enhance the antiproliferative effect by transfer of microRNAs in glioma cells
• Research progress of TREM2 in Alzheimer disease
• Effect of differential rearing environments on nicotine-stimulated locomotor activity and nicotinic acetylcholine receptor subtypes
• A novel GPCR mediates pancreatic cancer associated fibroblast-cancer cell interaction
• PD-1/PD-L1 checkpoint blockade in immune-antitumortherapy:advances and perspectives
• MicroRNA-10a promotes granulosa cells tumor development
• PID1,a new tumor-promoting gene in insulin resistance mediated acceleration of hepatocellular carcinoma development and progression
• Assembly of a highly stable luminescent Zn5 cluster and application to bio-imaging
• Chinese Journal of Pharmacology and Toxicology
• 基于組織和細胞G蛋白偶聯(lián)受體表達的新治療靶標的鑒定（英文）
• 炎癥免疫反應(yīng)軟調(diào)節(jié)——藥物研究新方向（英文）
• 治療癌癥及抗纖維化的新靶標的鑒定（英文）
• 抑制蛋白介導的G蛋白偶聯(lián)受體偏向性信號途徑及其在新藥發(fā)現(xiàn)中的應(yīng)用（英文）
• 基于G-蛋白偶聯(lián)受體激酶2抑制劑治療心力衰竭的合理藥物設(shè)計（英文）
• 藥物與天然產(chǎn)物:從動植物到人類疾病的治療（英文）
• Identification and optimization of a potent and highly selective D3 dopamine receptor agonist
• Abuse-related effects of synthetic cathinones:importance of DAT/SERT relationships
• Diazepam reduces synaptic GABA type areceptor availability via multiple trafficking mechanisms
• Cell-type specific examination of central amygdala dopamine receptor 2 expressing neurons as a translational target for pharmacological enhancement of extinction
• Targeting androgen receptor and trail:a novel treatment paradigm for breast cancer
• Cytoplasmic translocation of Cx32 mediates cisplatin resistance in ovarian cancer cells
• Discovery of a small molecule targeting ULK1-modulated cell death of triple negative breast cancer in vitro and in vivo
• Gecko crude peptides inhibit migration and lymphangiogenesis by down regulating the expression of VEGF-C in human hepatocellular carcinoma cells and human lymphatic endothelial cells
• Regulatory effects of GRK2 on GPCRs and possible use as a drug target
• Selective targeting p53~(WT) lung cancer cells harboring homozygous p53 Arg72 by an inhibitor of CypA
• DL0410,a candidate for anti-Alzheimer disease with multiple targets in multiple pathways
• Regulation of nitric oxide donor JS-K on tumor energy metabolism in H22 tumor-bearing mice
• Insulin-like growth factor-binding protein-3 inhibits IGF-1-induced proliferation of human hepatocellular carcinoma cells
• Combination of carboxyamidotriazole and 1-Methyl-L-tryptophan has synergistic inhibtory effects on programmed death 1 expression
• Development of an XBP1 agonist,HLJ2,as a potential therapeutic agent for ulcerative colitis
• Drug repurposing of histone deacetylase inhibitors that alleviate neutrophilic inflammation in acute lung injury and idiopathic pulmonary fibrosis via inhibiting leukotriene a4 hydrolase and blocking LTB4 biosynthesis
• Effects of methionine enkephalin on immune enhancement by reducing myeloid derived suppressor cells and reprogramming liver metabolism in colon cancer mice
• Involvement of PPARs in the regulation of brain CYP2D by growth hormone
• Discovery of a small-molecule bromodomain-containing protein 4 inhibitor that induces AMP-activated protein kinase-modulated autophagy-associated cell death in breast cancer
• A small-molecule activator of ULK1 that induces cytoprotective autophagy for Parkinson disease treatment
• Functionally diverse ligands modulate different activation states of the formyl peptide receptor 2,a G protein-coupled receptor
• CP-25 inhibits the functions of activated human B cells through regulating BAFF-TRAF2-NF-κB and TNF-alpha-TRAF2-NF-κB signaling
• SOD mimicAEOL-10150 improve lifespan and delay brain aging via inhibition of senescence-associated secretory phenotype in SAMR1 strain
• Protective action of aspirin and its against endothelial Nlrp3 inflammasome activation in response to LPS stimuli
• Identification of a novel autophagic inhibitor cepharanthine to enhance the anti-cancer property of dacomitinib in non-small cell lung cancer
• Hepato-protective effect of thymoquinone against acetaminophen induced liver injury is associated with regulation of JNK and AMPK signaling pathway
• Neurotransmitter systems in mouse airways
• Pharmacological characterizationof synthetic cannabinoid MAM-2201:radioligand binding and abuse-related effects
• Differentially expressed genes of HepG2 cells treated with gecko polypeptide mixture
• Glucuronidation is the dominating in-vivo metabolism pathway of herbacetin:elucidation of herbacetin pharmacokinetics after intravenous and oral administration in rats
• Topically applied hypericin exhibits skin penetrability on nude mice
• Biphasic modulation of chemerin peptide-induced calcium flux and ERK phosphorylation by amyloid beta peptide
• Pharmacokinetics and pharmacodynamics of cisatracurium in children undergoing cleft lip or cleft palate repair surgery
• Reassessment subacute MPTP-treated mice model of Parkinson disease
• Connexin 40-formed GJIC increases the phototoxicity of photodynamic therapy through ROS-and calcium-mediated pathways
• Inhibitory effect of compound NS5806 on cardiac transient outward potassium channel dependents on interaction between auxiliary subunits
• Involvement of cysteinyl leukotriene signaling in microglial morphological changes and CASP1 expression in vitro
• 歡迎投稿 歡迎訂閱