中國藥理學(xué)與毒理學(xué)雜志(2018年04期)
Chinese Journal of Pharmacology and Toxicology

目 錄

• Chinese Journal of Pharmacology and Toxicology
• Study,application and communication of traditional medicine among the Belt and Road Countries
• Pharmacological approach to restoring steroid sensitivity in respiratory diseases
• Atractylodin-loaded PLGA nanoparticles:formulation and characterization
• Traditional medicine/Herbal medicine situation in Iran
• Efficacy and safety validation of traditional products——current regulatory status in India
• Improving drug review systems to facilitate new drug development
• Targeting oncogenic transcription factors for cancer therapy
• A clinical and mechanistic study of topical bingpian-induced analgesia
• Pharmacological actions of miltirone in the modulation of platelet function
• Multi-functional pharmacological credence of triterpenoid 16-hydroxy betulinic acid isolated from Mikania cordata
• Renal protective effect of Ganoderma lucidum
• Pharmacophenomics: the systematical paradigm for pharmacology of traditional Chinese medicine
• Echinacoside and Cistanche tubulosa(Schenk) R. wight have male reproductive protection effect by targeting hypothalamic and rogen receptor
• Andrographolide as a potential anti-neuroinflammatory therapeutic:mechanisms of action and clinical utility
• Saponins from Paris forrestii(Takht.) H. Li displays potent activity against acute myeloid leukemia by suppressing RNF6/AKT/mTOR signaling pathway
• MCL3 exhibited anti-tumor activity mediated by NF-κB/IL-6/State3 pathway in glioma
• Identification of potential protein targets of atractylodin against cholangiocarcinoma
• BRAFV600E-dependent Mcl-1 stabilization leads to everolimus resistance in colon cancer cells
• Immunopotentiating activities and TLR4/MAPK related molecular mechanisms research of Lycium barbarum polysaccharide
• Nicotine protects against DSS colitis through regulating microRNA-124 and STAT3
• Study on mechanism of astragaloside Ⅳ in treatment of pulmonary fibrosis with epithelial-mesenchymal transition
• Gentiopicroside ameliorates LKB1/AMPK-dependent alcoholic hepatosteatosis via P2x7R-NLRP3 inflammasome
• Anti-depressant effects of Jieyu Anshen granule in chronic unpredictable mild stress-treated rats after ischemic stroke
• FOXO1 inhibition potentiates endothelial angiogenic functions in diabetes via suppression of ROCK1/Drp1-mediated mitochondrial fission
• Assessment of anti-diabetic potential of aqueous and ethanol extracts of Strophanthus hispidus stem bark in Wistar rats
• Neuroprotective effect of luteolin-7-O-β-D-glucuronide in a rat model offocal cerebral ischemia
• Melatonin prevents endothelial cell pyroptosis via regulation of long noncoding RNA MEG3/miR-223/NLRP3 axis
• GSK-3β inhibition induces cardioprotection via attenuating activation of NLRP3 inflammasome after acute myocardial infarction in rats
• Traditional therapeutics in the Nepal Himalaya:a trove of ethnomedicinal plant knowledge
• An updated role of astragaloside Ⅳ in heart failure
• Total saponins of Aralia elata(Miq) Seem protect tumor necrosis factor-α-induced human umbilical vein endothelial cells via PI3K/Akt and NF-κB signal pathways
• Study on smooth wheezing effect of polysaccharide of Cydonia oblonga Mill in bronchial asthma rat
• Antioxidant effect of a novel synthetic hydrogen sulfide releasing Danshensu derivative and its clinical implications
• Salvianolic acid B increases recombinant adeno-associated virus transduction through redirecting trafficking pathways and stabilizing perinuclear accumulations
• Analysis of lycopodiastrum casuarinoides transcriptome discovers lycodine-type alkaloid biosynthetic genes and genetic markers
• Activation of Nrf2 attenuates pulmonary vascular remodeling via inhibiting endothelial-to-mesenchymal transition
• Pleurotus citrinopileatus alleviates alcohol-induced fatty liver via upregulating AMPK signaling
• Mechanism and impact of a novel allosteric AMPA receptor modulator on protection against respiratory depression
• Behavioral defects induced by chronic social defeat stress are protected by momordica charantia polysaccharides via attenuation of JNK3/PI3K/AKT neuroinflammatory pathway
• Differentially expressed genes of HepG2 cells treated with gecko polypeptide mixture
• Metabolic heterogeneity of gastric cancer cell lines
• Salvianolic acid A attenuates vascular remodeling in pulmonary arterial hypertension rats induced by monocrotaline
• A combinatorial approach to study hepatoprotective activity of Acanthus ilicifolius leaf extract against hepatocellular carcinoma(HCC)
• Berberine ameliorates chronic unpredictable mild stress induced depressive like behaviors and elevating Keap1-Nrf2 antioxidant signaling pathways
• Discovery of natural BH3 mimetics and research on related mechanism
• Anti-tumor effect of Hinesol on liver cancer via downregulating MEK/ERK and NF-κB pathway in SMMC-7721 and LM3cells
• Protopanaxadiol derivative DDPU improvesbehaviorand cognitive deficitin AD mice involving regulation of both ER stress and autophagy
• Guizhi Fuling Wan reverses drug resistance by regulating PTEN and MTDH in ovarian cancer SKOV3/DDP Cells
• Toll-like receptor 4-related regulation of Ornithogalum caudatum extract on inflammatory responses in LPS activated macrophages
• Network pharmacology deciphering multiple mechanisms of volatiles of Wendan granule for treatment of senile dementia
• Anti-tumor activity and molecular mechanism of C_3C_(12)PPD in lung cancer
• Gentiopicroside,originated from Gentiana macrophylla Pall,possesses antiarthritic efficacy in adjuvant-induced arthritis rats
• Network mechanism on effective constituents from Polygala Tenuifolia for anti-Alzheimer Disease
• Research development of Carpesii Fructus
• Effect and mechanism of Huanglianjiedu decoction on high fat-induced atherosclerosisrats and metabolomics study by ultra-performance liquid chromatography-mass spectrometry
• Metformin and tanshinone IIA as ethnodrugs protect heart against injury by inhibiting microRNA-1
• Liuwei Dihuang Decoction improves cognitive impairments via regulating immune system in APP/PS1 transgenic mouse,a mouse model of Alzheimer disease
• Water-soluble extract of clove inhibits in vitro and in vivo growth of colon cancer by inducing autophagy
• Zn-doped CuO nanocomposites inhibit in vitro and in vivo growth of pancreatic cancer by inducing autophagy through AMPK/mTOR pathway
• Research advances in cardiovascular protective effects of flavonoids
• Impacts of maternal LPS exposure on proinflammatory cytokines and DMEs expression in mouse offspring
• G_(αi) and G_(βγ) subunits have opposite effects on dexmedetomidine-induced sedation
• Anti-diabetes effects and mechanisms of a Chinese herbal medicine preparation JQ-R in diabetic KKAy mice and in vitro
• Inhibitory effect of ZX-1201 on pancreatic cancer and the relevant molecular mechanism
• Network pharmacology study of Chinese medicine Xiao-Xu-Ming decoction based on vasoconstrictor related GPCR targets
• Anti-esophagus cancer activity and mechanism of DN3,a novel natural diterpenoid derivative,as a dual inhibitor of glycolysis and oxidative phosphorylation
• Ganoderic acid A from Ganoderma lucidumretard ADPKD renal cyst development via down-regulating Ras/MAPK signaling pathway
• WM130 preferentially inhibits hepatic cancer stem-like cells by suppressing AKT/GSK3β/β-catenin signaling pathway
• Granulin A synergizes with cisplatin to inhibit the growth of human hepatocellular carcinoma
• Relationship between PI3K/Akt signal and its downstream pathway and cardiovascular disease
• Zuo Jin Wan formula inhibits cisplatin-resistance of gastric cancer cells via mitochondrial translocation of cofilin-1
• Research advances in antiplatelet activation of water soluble compounds in Salvia miltiorrhiza
• Research method of psoriasis based on HaCaT cells
• LW-AFC,a new formula derived from Liuwei Dihuang decoction,ameliorates behavioral and pathological deterioration via modulating the neuroendocrineimmune system in Alzheimer disease mouse models
• Withaferin A exerts anti-tumor effects in glioblastoma cells by arresting cell cycle at G_2/M phase
• Saffron: a potential immunological adjuvant in anti-tumor therapy
• Neonatal activation of Pxr results in persistent altered expression of DMEs in adult mice
• Total flavonoids of bugloss limits left ventricular remodeling after myocardial infarction in mice
• Construction of NIM sub-network regulated by Liuwei Dihuang decoction and its characteristics
• Effect of Xingnaojing injection on intestinal mucosal barrier in septicemia and intracerebral hemorrhage mice
• Synthesis and tumor resistance reverse activities of α-hederagenin-type ring-A fused pyrazine derivatives
• Bergapten attenuates D-galactose-induced immunosenescence in BALB/c mice
• Epac1/Rap1 signaling pathway is involved in the pathogenesis of myocardial ischemia/reperfusion injury in rats
• Xiao-Xu-Ming decoction protects against chronic cerebral ischemia injury in rats and profile of differentially expression proteins analysis in hippocampus
• NAD replenishment with nicotinamide mononucleotide protects blood-brain barrier integrity and attenuates delayed tissue plasminogen activator-induced haemorrhagic transformation after cerebral ischaemia
• Neuroprotective effect of Liu Wei Di Huang Tang on adult hippocampal neurogenesis in mice
• Compound Astragalus and Salvia miltiorrhiza extract exerts anti-tumor activity by intervening the interaction of microRNA-145/microRNA-21 and Smad3C/3L phos-phorylation in hepatocellular carcinoma
• Molecular Mechanism of Aconite-Ginger Muscle against Myocardial Ischemia Injury Based on Network Pharmacology
• Metabolism alternation of schisandra chinensis in carbon tetrachloride-intoxicated rats and patients with advanced hepatocellular carcinoma
• Effect of AngongNiuhuang Pill on neurological function and intestinal mucosal barrier in intracerebral hemorrhage mice
• ~1H-NMR based metabolomics approach to evaluate effect of Cydonia oblanga Miller total flavonoid on atherosclerosis apoE~(-/-) mice
• PID1 based connection of insulin resistance to hepatocellular carcinogenesis
• Influence of genetic polymorphisms in drug metabolism enzymes and transporters on pharmacokinetics of different fluvastatin formulations
• Novel Zn-doped CuO nanocomposites inhibit tumor growth in vitro and in vivo:role of reactive oxygen species-dependent apoptosis and autophagy cross-linked by NF-kappaB pathway
• Cardioprotective effect of Danshen injectable powder on pressure overloadinduced ventricular remodeling in rats and isoproterenol induced myocardial injury in mice
• Screening for potential biomarkers of traditional Chinese medicinechest impediment syndromesbased on plasma metabonomics
• Network mechanism of effective constituents from the compound Yizhihao against influenza
• Progress of traditional medicines for treatment of ischemic stroke
• Protective effect and mechanism of ginsenoside Rg1 on H_2O_2 induced hippocampal neurons aging due to down-regulate NOX2 mediated NLRP1 inflammasome activation in vitro
• Enhancement of exposure and reduction of elimination for paeoniflorin or albiflorin via co-administration with total peony glucosides and hypoxic pharmacokinetics comparison
• A novel zebrafish vascular injury model for asseessing drug efficancy of Yangxue Qingnao granules
• Angiogenesis function of astragaloside Ⅳ in rats with myocardial infarction via PKD1-HDAC5-VEGF pathway
• Alcohol promotes renal fibrosis by activating Nox-mediated DNA methylation of Smad7
• Proteomics analysis on hypolipidemic mechanisms of total phenylpropanoid glycosides from Ligustrum robustum(Roxb.) Blume in hamsters fed a high fat diet
• Neuroprotective effects of saffron on chronic focal cerebral ischemia through inhibiting glial scar formation in rats
• NQO1 dependent non-canonical necroptosis mediated by ROS and RIP1/RIP3 in parallel in glioma cancer cells
• Exosomes as potential drug delivery tools for treatment of cardiovascular diseases
• Curcumin,from health product to medicine
• SIRT3:a potential target for CHF?
• Correlation between insulin resistance index and hypoxia in obese rat model base on blood gas analyzing
• Traditional Chinese medicine target identification based on "Target Fishing" strategy
• The mTORC1 signaling network underlying the pathogenesis and treatment of depression: new insights into rapid-acting antidepressant therapies
• Association between red blood cell increase and gut microbiota induced by high-fat diet
• Protective effect of luteolin-7-O-β-D-glucuronide against oxygenglucose deprivation-induced H9C2 cardiomyocytes injury
• Effect and mechanism of baicalin and geniposide on excitotoxicity of acute cerebral ischemia
• Comparison of preventive and therapeutic effect on cardio-cerebral ischemic disease between salvianolic acids and aspirin
• Neural stem cells derived from sporadic Alzheimer disease iPSCs exhibit excessive cell apoptosis and premature neuronal differentiation
• Anti-atherosclerotic effect of extract of traditional Chinese medicine formula Dan-yi-lian in ApoE~(-/-) mice
• Analysis of development trend of Chinese medicine health products based on history of western health products development
• Enrichment of flavonoid aglycones in licorice extract enhanced anti-inflammatory potential,but its hypnotic effect was not altered
• Dihydroquercetin ameliorates alcoholic liver steatosis through P2x7R-NLRP3 inflammasome pathway
• Transcriptional regulation effect of constituents in Polygonum multiflorum Thunb. based on human progesterone X receptor(hPXR) mediated CYP3A4 rapid screening system
• Wnt1/β-catenin signaling up-regulates spinal VGLUT2 expression to maintain neuropathic pain in mice
• Study on enzymatic extraction process of polysaccharide from Urena lobata L. and investigation on its antioxidant activity
• Research progress on pharmacological effect and mechanism of baicalein in Parkinson diseases
• Evodiamine activates cellular apoptosis through suppressing PI3K/AKT and activating MAPK in glioma
• Genetic and epigenetic predispositions underlying cardiovascular outcomes among patients treated with clopidogrel and aspirin
• ~1H-NMR-based Metabolomic approach to evaluating total flavonoids of Ocimum Basilicum Linn in apolipomtein E knockout mice
• Effect and mechanism of LW-AFC on chronic unpredictable mild stress-induced mood and cognition impairment of mice
• Effect of Qi Kwai Granule particles on expression of TGF-β1 and MCP-1 in kidney of diabetic nephropathy rats
• Antitumor activityand mechanism of JD20,a newly synthetic analog of natural ent-kaurane diterpenoid
• 《中國藥理學(xué)與毒理學(xué)雜志》簡介