Effect of midazolam and propofol on cytokine balance in patients undergoing cardiac valve replacement

摘要： <正> Objective To compare the effect of midazolam and propofol on cytokine balance in patients undergoing cardiac June 2003 Vol12 No2 valve replacement under CPB. Methods Twenty NYHA class II - 333 patients with rheumatic heart disease scheduled for elective cardiac valve replacement under CPB were randomy divided into 2 groups: midazolam group (M, n = 10) and propofol group (P, n = 10). Patients with preoperative hepatic and renal dysfunctions were premedicated intramuscular morphine 0. 1 mg · kg-1 and oral diazepam 0.1 mg·kg-1 . Anesthesia was induced withmidazolam 0. 06 -0.1 mg· kg-1 (group M) or propofol1.0-1.5 mg·kg-1 (gropu P) and scopolamine 0.6 mg, fentanyl 4-10 μg · kg-1, vecuronium 0. 1 mg · kg-1 and lidocaine 1. 5 mg·kg-1,and maintained with intermittent iv boluses of midazolam 0. 04 - 0.1 mg· kg-1(group M) or propofol intravenous infusion at a rate of 3 - 5 mg· kg-1 · h-1 supplemented with intermittent boluses of fentanyl and vecuronium. PETCO2 was maintained at 30 -40 mmHg during mech ... （共1頁）