Combinationoffasudilandcelecoxibpromotestherecoveryofinjuredspinalcordinratsbetterthancelecoxiborfasudilalone

摘要： Resistancemechanismsofrho-associatedkinase(ROCK)inhibitorsareassociatedwiththeenhancedexpressionofcyclooxygenase-2(COX-2).ThetherapeuticeffectsofROCKonnervoussystemdiseasesmightbeenhancedbyCOX-2inhibitors.ThisstudyinvestigatedthesynergisticeffectofthecombineduseoftheROCKinhibitorfasudilandaCOX-2inhibitorcelecoxibonspinalcordinjuryinaratmodelestablishedbytransectingtherighthalfofthespinalcordatT11.Ratmodelswereorallyadministratedwithcelecoxib(20mg/kg)and/orintramuscularlywithfasudil(10mg/kg)for2weeks.ResultsdemonstratedthatthecombineduseofcelecoxibandfasudilsignificantlydecreasedCOX-2andRhokinaseIIexpressionsurroundingthelesionsiteinratswithspinalcordinjury,improvedthepathomorphologyoftheinjuredspinalcord,andpromotedtherecoveryofmotorfunction.Moreover,theeffectsofthedrugcombinationwerebetterthancelecoxiborfasudilalone.Thisstudydemonstratedthatthecombineduseoffasudilandcelecoxibsynergisticallyenhancedthefunctionalrecoveryofinjuredspinalcordinrats. ... （共5頁）