Sarcopeniaandlivertransplant:Therelevanceoftoolittlemusclemass
摘要: Lossofmusclemassandfunctionisacommonoccurrenceinbothpatientswithdecompensatedcirrhosisandthoseundergoinglivertransplantation.Sarcopeniaisassociatedwithmorbidityandmortalitybeforeandafterlivertransplantation.Theabilityofskeletalmusclemasstorecoveraftertransplantisquestionable,andlongtermadverseeventsassociatedwithpersistentsarcopeniahavenotbeenwellstudied.Limiteddataisavailableexaminingmechanismsbywhichdecreasedmusclemassmightdevelop.Itisnotclearwhichinterventionsmightreducetheprevalenceofsarcopeniaandassociatedhealthburdens.However,measurestoeitherdecreaseportalhypertensionorimprovenutritionappeartohavebenefit.Researchonsarcopeniainthelivertransplantsettingishamperedbydifferingmethodologytoquantifymusclemassandvariedthresholdsdeterminingthepresenceofsarcopenia.Oneareahighlightedinthisreviewistheheterogeneityusedwhendefiningsarcopenia.Thehealthconsequences,clinicalcourseandpotentialpathophysiologicmechanismsofsarcopeniainthesettingofcirrhosisandlivertransplantationarefurtherdiscussed. ...
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