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Glucagon-likepeptide-1receptoragonistsfavorablyaddressallcomponentsofmetabolicsyndrome

WorldJournalofDiabetes 頁數(shù)： 8 2016-10-15
摘要： Cardiovasculardeathistheleadingcauseofmortalityforpatientswithtype2diabetesmellitus.Theetiologyofcardiovasculardiseaseindiabetesmaybedividedintohyperglycemiaperseandfactorsoperatingthroughcomponentsofmetabolicsyndrome(MetS).Hyperglycemiacausesdirectinjurytovascularendotheliumandpossiblyoncardiacmyocytes.MetSisaclusterofriskfactorslikeobesity,hyperglycemia,hypertensionanddyslipidemia.Theincidenceofthissyndromeisrisingglobally.Glucagon-likepeptide-1receptoragonists(GLP-1RA)areagroupofdrugs,whichaddressallcomponentsofthissyndromefavorably.Experimentalevidencesuggeststhattheyhavefavorableactionsonmyocardiumaswell.SeveralcompoundsbelongingtoGLP-1RAclassareinmarketnowandalargenumberawaitingtheirentry.Although,originallythisclassofdrugsemergedasatreatmentfortype2diabetesmellitus,morerecentdatageneratedrevealedbeneficialeffectsonmultiplemetabolicparameters.Wehavestudiedliteraturepublishedbetween2000and2016tolookintoeffectsofGLP-1RAoncomponentsofMetS.Resultsfromrecentlyconcludedclinicaltrialssuggestthatsomeofthemoleculesinthisclassmayhavefavorableeffectsoncardiovascularoutcome. ... （共8頁）

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