Anoverlookedeffectofsystemicanticholinergics:alterationonaccommodationamplitude

摘要： AIM:Toinvestigatetheeffectoforalsolifenacinsuccinate,tolterodine-L-tartarateandoxybutininhydrochloride(HCl)onaccommodationamplitude.·METHODS:Femaleoveractivebladdersyndrome(OAB)patientswhowereplannedtouseoralanticholinergics,patientsthatusessolifenacinsuccinate5mg(GroupI,n=25),tolterodine-L-tartarate4mg(GroupII,n=25),andoxybutininHCl5mgb.i.d.(GroupIII,n=25)andagematchedhealthyfemalesubjects(GroupIV,n=25)wererecruitedandcompleteophthalmologicalexaminationandaccommodationamplitudeassessmentweredoneatbaselineand4wkafterinitiationoftreatment.·RESULTS:Themeanageof100consecutivefemalesubjectswas51.6±5.7(40-60)yandtherewerenostatisticallysignificantdifferencewithregardtothemeanage(P=0.107)andbaselineaccommodationamplitude(P=0.148)betweenstudygroups.Alltreatmentgroupsshowedasignificantdecreaseinaccommodationamplitudefollowinga4-weekcourseofanticholinergictreatment(P=0.008inGroupI,P=0.002inGroupII,P=0.001inGroupIII),buttherewasnostatisticallysignificantdifferenceinGroupIV(P=0.065).·CONCLUSION:A4-weekcourseoforalanticholinergictreatmenthavestatisticallysignificanteffectonaccommodationamplitude.Cliniciansshouldavoidbothoverestimatingthisresult,asthiswouldunnecessarilyrestricttherapeuticpossibilities,andalsounderestimatingitwhichmayleadtodrugintolerance. ... （共3頁）